β-Cyclodextrin Nanosponge Hydrogels as Drug Delivery Nanoarchitectonics for Multistep Drug Release Kinetics

The reaction of β-cyclodextrin with suitable bifunctional cross-linkers (such as carboxylic acids dianhydrides) provides 3D nanoporous polymers referred to cyclodextrin nanosponges (CDNS). swelling ability many CDNS can be exploited confine small active molecules, such drugs, in the resulting hydrogel, thus providing drug-loaded hydrogels. This raises an increasing interest toward hydrogels biomaterials for controlled drug delivery due their nontoxicity, biocompatibility, and biodegradability. release kinetics a carrier is often influenced by physical chemical properties hydrogel nanoarchitectonics drug–polymer interactions across network. A deep understanding, at molecular level, mechanisms underlying dynamics polymer matrix relation macroscopic kinetic key step rational design systems. In this study, nanosponge-hydrogels are prepared cross-linking pyromellitic dianhydride corresponding loaded anti-inflammatory piroxicam. translational optimized formulation investigated 1H high resolution magic angle spinning (HR-MAS) NMR spectroscopy variable observation times. microscale results, compared vitro performed on much longer time-range, reveal continuous Fickian within multistep prolonged combined mode adsorption drug-to-polymer network β-cyclodextrin–drug complex formation.